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. 2024 Feb 1;11:1352025. doi: 10.3389/fcvm.2024.1352025

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© 2024 Los, Mensink, Mohammadnia, Opstal, Damman, Volleberg, Peeters, van Royen, Garcia-Garcia, Cornel, El Messaoudi and van Geuns.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Virtual histology intravascular ultrasound (VH-IVUS) image of atherosclerotic plaque. Based on the reflected ultrasound signals, VH-IVUS automatically provides a colorized tissue map of plaque composition: fibrous (dark green), fibrofatty (light green), calcified (white) and necrotic core (red). (A) Longitudinal VH-IVUS image of an atherosclerotic lesion in the right coronary artery. (B) Cross-sectional images within the region of interest showing different tissue compositions. (C) A thin-cap fibroatheroma (TCFA), characterized as a necrotic-core rich lesion without a clear overlying fibrous cap (arrows). Reused with permission from Kuroda et al. (126).