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. 2024 Feb 14;80(1):ujad017. doi: 10.1093/biomtc/ujad017

TABLE 2.

Simulation result for Scenario 1b with 2 stages and 3 treatment options (sample size N = 1000, 100 replications).

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Method Stage 1 Stage 2 Overall
Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic
T-RL Y 1 as outcome 77.75 (1.32) 4.98 (0.07) 3.35 (0.09) 65.51 (5.20) 4.31 (0.11) 2.74 (0.28) 43.89 (5.33) 9.29 (0.14) 6.09 (0.28)
Y 2 as outcome 21.31 (1.19) −0.36 (0.07) 4.94 (0.07) 77.36 (13.12) 3.89 (1.06) 4.20 (0.30) 18.51 (6.74) 3.53 (1.05) 9.14 (0.30)
MOT-RL: w = (0.3, 0.7)
100% tolerant 71.07 (12.41) 3.11 (0.78) 4.39 (0.20) 96.02 (2.81) 4.76 (0.16) 4.58 (0.05) 69.08 (12.04) 7.87 (0.77) 8.97 (0.21)
90% tolerant 71.59 (12.46) 3.12 (0.78) 4.38 (0.20) 96.16 (2.73) 4.76 (0.16) 4.58 (0.05) 69.66 (12.11) 7.88 (0.78) 8.96 (0.21)
70% tolerant 72.64 (12.19) 3.10 (0.76) 4.39 (0.20) 96.38 (2.83) 4.70 (0.17) 4.58 (0.05) 70.82 (11.94) 7.80 (0.78) 8.96 (0.20)
50% tolerant 73.94 (12.01) 2.94 (0.83) 4.40 (0.23) 96.62 (2.96) 4.26 (0.28) 4.51 (0.06) 71.23 (11.89) 7.19 (0.83) 8.91 (0.24)
MOT-RL: w = (0.4, 0.6)
100% tolerant 82.49 (12.28) 3.78 (0.71) 4.31 (0.23) 96.08 (3.13) 4.76 (0.19) 4.58 (0.06) 79.18 (12.36) 8.54 (0.72) 8.90 (0.24)
90% tolerant 82.74 (12.30) 3.79 (0.70) 4.31 (0.24) 96.08 (3.13) 4.76 (0.19) 4.58 (0.06) 79.39 (12.36) 8.55 (0.71) 8.89 (0.24)
70% tolerant 83.02 (12.57) 3.82 (0.69) 4.30 (0.23) 96.18 (3.15) 4.74 (0.19) 4.58 (0.06) 80.70 (12.69) 8.55 (0.71) 8.88 (0.24)
50% tolerant 84.13 (12.27) 3.76 (0.63) 4.33 (0.25) 96.52 (2.75) 4.61 (0.24) 4.55 (0.11) 82.98 (12.45) 8.37 (0.69) 8.88 (0.28)
MOT-RL: w = (0.5, 0.5)
100% tolerant 91.19 (9.96) 4.35 (0.51) 4.28 (0.23) 95.99 (3.10) 4.76 (0.18) 4.58 (0.06) 89.53 (10.49) 9.10 (0.56) 8.86 (0.23)
90% tolerant 91.54 (9.94) 4.36 (0.50) 4.28 (0.24) 95.99 (3.10) 4.76 (0.18) 4.58 (0.06) 89.86 (10.52) 9.12 (0.56) 8.86 (0.24)
70% tolerant 92.27 (9.89) 4.37 (0.50) 4.27 (0.24) 95.99 (3.10) 4.75 (0.19) 4.58 (0.06) 90.55 (10.57) 9.12 (0.56) 8.85 (0.24)
50% tolerant 93.07 (9.58) 4.27 (0.53) 4.25 (0.29) 96.30 (2.66) 4.68 (0.21) 4.56 (0.11) 91.56 (10.05) 8.96 (0.60) 8.81 (0.31)
MOT-RL: w = (0.6, 0.4)
100% tolerant 90.36 (10.73) 4.72 (0.27) 4.04 (0.45) 95.68 (3.27) 4.74 (0.19) 4.58 (0.06) 88.29 (11.35) 9.46 (0.35) 8.62 (0.46)
90% tolerant 90.46 (10.70) 4.73 (0.27) 4.03 (0.47) 95.68 (3.27) 4.74 (0.19) 4.58 (0.06) 88.36 (11.32) 9.47 (0.35) 8.61 (0.48)
70% tolerant 91.07 (10.54) 4.74 (0.24) 4.04 (0.46) 95.84 (2.80) 4.73 (0.21) 4.57 (0.11) 89.03 (10.95) 9.47 (0.30) 8.61 (0.47)
50% tolerant 92.23 (9.98) 4.68 (0.29) 4.06 (0.44) 96.17 (1.91) 4.70 (0.23) 4.55 (0.17) 90.50 (10.12) 9.38 (0.37) 8.61 (0.46)
MOT-RL: w = (0.7, 0.3)
100% tolerant 84.50 (10.11) 4.88 (0.17) 3.67 (0.46) 95.04 (4.06) 4.71 (0.22) 4.56 (0.08) 78.72 (10.65) 9.59 (0.27) 8.23 (0.47)
90% tolerant 84.57 (10.15) 4.89 (0.17) 3.67 (0.47) 95.08 (3.88) 4.71 (0.22) 4.56 (0.08) 78.83 (10.53) 9.59 (0.28) 8.23 (0.48)
70% tolerant 84.97 (10.11) 4.88 (0.16) 3.66 (0.47) 95.37 (3.25) 4.70 (0.24) 4.55 (0.15) 79.50 (10.42) 9.58 (0.27) 8.21 (0.50)
50% tolerant 85.25 (10.02) 4.87 (0.17) 3.64 (0.45) 95.83 (1.99) 4.69 (0.26) 4.52 (0.21) 80.20 (10.36) 9.55 (0.30) 8.16 (0.49)

The Inline graphic column indicates the empirical mean and standard error (SE) of the percentage of subjects whose estimated treatment set includes the actual optimal treatment, which is recorded for stage 1, stage 2, and both stage 1 and stage 2 (overall). The Inline graphic column presents the empirical mean and SE of the estimated counterfactual mean rewards of i th objective at stage j, Rij (i, j = 1, 2), which are obtained from true rewards and the estimated optimal (or tolerant) regime. The Inline graphic column presents the empirical mean and SE of the estimated counterfactual mean outcome of the ith objective.