Table 2.
Treatment Groups | Time (Days Post-Exposure) | BAL Alveolar Macrophages (106) | BAL Neutrophils (106) | BAL Eosinophils (106) |
---|---|---|---|---|
| ||||
Air PMET731 | Day 4 | 4.87±0.41 | 0.008±0.008 | 0.00±0.00 |
5.68±0.27 | 0.46±0.12 | 0.00±0.00 | ||
Air PMET731 | Day 30 | 4.38±0.20 | 0.008+0.005 | 0.00±0.00 |
5.07±0.53 | 0.38±0.12 | 0.00±0.00 | ||
Air PMET885 | Day 4 | 4.68±0.52 | 0.020±0.001 | 0.03±0.02 |
12.7±1.9* | 4.15±0.43* | 2.29±0.74* | ||
Air PMET885 | Day 30 | 4.42±0.28 | 0.128±0.12 | 0.00±0.00 |
91.1±8.3* | 18.5±3.8* | 3.07±1.06* | ||
Air PMET540 | Day 4 | 4.61±0.17 | 0.005±0.005 | 0.00±0.00 |
7.81+0.60* | 0.33±0.08 | 0.010+0.01 | ||
Air PMET540 | Day 30 | 5.36±0.50 | 0.008±0.003 | 0.00±0.00 |
6.19 ±0.46 | 0.030±0.010 | 0.020±0.02 |
Note. Male Sprague-Dawley rats (n=6/treatment group within a time point) were exposed to a target concentration of 25mg/m3 × 4hr/d × 4 d. For BAL cell differential analysis, 200 cells/rat were counted.
Significantly different from corresponding air control within a time point (p<0.05).