Table 3.
Lung concentration of specific metals after exposure to PMET731, PMET885, and PMET540 thermal spray coating aerosols.
| Metal (time post-exposure) | Control (μg/g dry lung tissue) | Thermal Spray Coating (μg/g dry lung tissue) | Thermal Spray Coating minus Air Control (% metal remaining in lungs) |
|---|---|---|---|
|
| |||
| Ni | Air | PMET885 | Ni - Air |
| 0 d | 0.271±0.06 | 168±10* | 168 |
| 1 d | 0.227±0.05 | 166±12* | 166 (98.8%) |
| 4 d | 0.230 + 0.05 | 89.5±1.2* | 89.3 (53.2%) |
| 30 d | 0.290±0.03 | 35.9±1.6* | 35.6 (21.2%) |
| Zn | Air | PMET540 | Zn - Air |
| 0 d | 88.0±4.9 | 161±4.6* | 73 |
| 1 d | 85.2±2.1 | 104±6.4* | 18.8 (25.8%) |
| 4 d | 87.9±2.2 | 83.3±1.7 | −4.6 (−6.30%) |
| 30 d | 79.8±2.4 | 74.2±3.1 | −5.6 (−7.67%) |
| Cr | Air | PMET731 | Cr - Air |
| 0 d | n.d. | 48.7±2.7* | 48.7 |
| 1 d | n.d. | 48.6±1.8* | 48.6 (99.8%) |
| 4 d | n.d. | 26.3±2.5* | 26.3 (54.0%) |
| 30 d | n.d. | 11.3±1.7* | 11.3 (23.2%) |
| Fe | Fe - Air | ||
| 0 d | 315±13 | 463±25* | 148 |
| 1 d | 326±11 | 522±26* | 196 (132%) |
| 4 d | 357±20 | 378±23 | 21 (14.2%) |
| 30 d | 392±9.5 | 423±25 | 31 (20.9%) |
| Mn | Mn - Air | ||
| 0 d | 0.800±0.04 | 2.67±0.11 * | 1.87 |
| 1 d | 0.780±0.02 | 2.33±0.07* | 1.55 (82.8%) |
| 4 d | 0.810±0.01 | 1.74±0.08* | 0.93 (49.7%) |
| 30 d | 0.840±0.08 | 1.06±0.04* | 0.22 (11.8%) |
Note. Male Sprague-Dawley rats (n=6/treatment group within a time point) were exposed to a target concentration of 25mg/m3 × 4hr/d × 4 d.
*
Specific metal is significantly different from corresponding air control within a time point (p<0.05). n.d. = below level of quantification.