Table 1.
Entry | Cmpd | R | Buffer pH |
Time (h) |
% Yield 1 (% ee) |
% Yield 2 (% ee) |
---|---|---|---|---|---|---|
1[b] | 1a/2a | 7.5 | 16 | 46 (>98) | 30 (99) | |
2[b] | 1b/2b | n-Hex | 9.0 | 12 | 46 (>98) | 32 (>99) |
3 | 1c/2c | 7.5 | 16 | 48 (>99) | 35 (>99) | |
4 | 1d/2d | 7.5 | 15 | 47 (>99) | 36 (96) | |
5 | 1e/2e | 7.5 | 15 | 46 (>99) | 35 (>99) | |
6 | 1f/2f | 8.6 | 14 | 45 (>99) | 33 (>99) | |
7 | 1g/2g | 7.5 | 16 | 45 (>99) | 33 (98) | |
8[b],[c] | 1h/2h | 9.5 | 60 | 44 (>99) | 30 (89) |
Reactions on a 1 g scale with 10 wt% lipoprotein lipase from Burkholderia sp., 8:1 50 mM phosphate buffer:toluene unless otherwise noted.
30 wt% lipase.
100 mM phosphate buffer.