Table 1.
Baseline characteristics of participants enrolled in ISCHEMIA-CKD by BMI category*.
| Baseline BMI (Kg/m2) | P value | |||
|---|---|---|---|---|
| <25.0 (N=274) |
≥25.0 and <30.0 (N=246) |
≥30.0 (N=253) |
||
| Demographics | ||||
| Age at randomization (years) | 62 (54, 69) | 65 (56, 72) | 63 (57, 69) | 0.026 |
| Male | 70.4 | 72.0 | 63.6 | 0.10 |
| Clinical History | ||||
| Hypertension | 87.2 | 93.0 | 96.0 | <0.001 |
| Diabetes | 47.1 | 54.5 | 70.8 | <0.001 |
| Prior myocardial infarction | 15.8 | 16.3 | 19.8 | 0.42 |
| Cigarette smoking | 0.06 | |||
| Never smoked | 52.6 | 48.4 | 42.3 | |
| Former smoker | 35.8 | 40.7 | 48.6 | |
| Current smoker | 11.7 | 11.0 | 9.1 | |
| Prior PCI | 13.9 | 20.3 | 22.9 | 0.023 |
| Prior CABG | 2.9 | 3.3 | 4.7 | 0.50 |
| Atrial fibrillation/atrial flutter | 6.6 | 7.3 | 13.0 | 0.019 |
| Prior stroke | 5.8 | 9.3 | 11.5 | 0.070 |
| Prior peripheral artery disease | 6.2 | 8.1 | 4.3 | 0.22 |
| History of HF (diagnosis of prior HF or LVEF <45%) | 24.5 | 22.8 | 28.9 | 0.27 |
| LVEF (%) | 59 (50, 64) | 60 (50, 65) | 56 (50, 61) | 0.22 |
| HF status over the past month, n/N (%) | 0.36 | |||
| None | 50.0 | 47.6 | 41.9 | |
| NYHA Class I | 15.7 | 18.7 | 18.2 | |
| NYHA Class II/III/IV | 34.3 | 33.7 | 39.9 | |
| Laboratory Values | ||||
| LDL cholesterol (mg/dL) | 81.0 (55.0, 107.5) | 87.0 (65.0, 110.0) | 83.0 (57.0, 120.0) | 0.18 |
| HDL cholesterol (mg/dL) | 40.2 (34.0, 50.3) | 41.0 (34.0, 49.5) | 36.9 (30.9, 47.0) | <0.001 |
| Renal Disease-related Measures | ||||
| Estimated GFR from enrollment among those not on dialysis (mL/min/1.73m2) | 22 (16, 27) | 23 (17, 26) | 23 (18, 27) | 0.83 |
| On dialysis at baseline | 64.2 | 47.2 | 47.0 | <0.001 |
| Duration of dialysis (years) | 3 (1, 6) | 3 (1, 5) | 2 (1, 4) | 0.06 |
*
Categorical variables are displayed as percentages of the total; continuous variables are displayed as median (interquartile range).
BMI, body mass index; CABG, coronary artery bypass grafting; CV, cardiovascular; GFR, glomerular filtration rate; HDL, high density lipoprotein; HF, heart failure; LVEF, left ventricular ejection fraction; LDL, low density lipoprotein; NYHA, New York Heart Association, PCI, percutaneous coronary intervention