. Author manuscript; available in PMC: 2025 Feb 1.

Published in final edited form as: Am J Med. 2023 Nov 3;137(2):163–171.e24. doi: 10.1016/j.amjmed.2023.10.024

Table 4b.

Health status scores for participants enrolled in the ISCHEMIA-CKD trial as a function of BMI (per 5kg/m²).^a

Health Status Measure	Month	Odds Ratio (95% CI)^b	Treatment Interaction P-value
SAQ-7 Summary Score	0	0.84 (0.75, 0.95)
	3	0.92 (0.81, 1.04)	0.34
	12	0.90 (0.79, 1.02)	0.19
	24	1.01 (0.88, 1.15)	0.91
SAQ-7 Angina Frequency Score	0	0.94 (0.81, 1.08)
	3	0.88 (0.75, 1.04)	0.35

	12	0.86 (0.74, 1.02)	0.06
	24	0.93 (0.77, 1.11)	0.51
SAQ-7 Quality of Life Score	0	0.96 (0.85, 1.09)
	3	0.97 (0.85, 1.11)	0.89
	12	0.97 (0.85, 1.11)	0.37
	24	1.07 (0.93, 1.24)	0.59
SAQ-7 Physical Limitation Score	0	0.70 (0.60, 0.81)
	3	0.87 (0.74, 1.04)	0.16
	12	0.82 (0.69, 0.97)	0.11
	24	0.84 (0.69, 1.03)	0.79
Rose Dyspnea Scale	0	0.68 (0.60, 0.78)
	3	0.81 (0.70, 0.93)	0.82
	12	0.79 (0.68, 0.93)	0.58
	24	0.88 (0.75, 1.02)	0.43
EQ-5D Visual Analog Scale	0	0.81 (0.71, 0.92)
	3	0.87 (0.77, 0.99)	<0.001
	12	0.98 (0.86, 1.12)	0.97
	24	0.93 (0.81, 1.08)	0.73

CI, confidence interval; EQ-5D, European Quality of Life–5 Dimensions; SAQ, Seattle Angina Questionnaire.

For the Seattle Angina Questionnaire-7 (SAQ-7) and the Euroqol-5D (EQ-5D) scores, a higher score indicates better health status. For example, at baseline, a higher BMI was associated with an OR of 0.84 with the SAQ-7 summary score indicating higher (per 5 kg/m2 increase) BMI was associated with a lower SAQ-7 score and thus worse health status. In contrast, higher Rose Dyspnea Scale (RDS) score represents worse dyspnea. For consistency, the OR for RDS was evaluated for the interpretation of RDS (e.g. more or less dyspnea) such that the interpretation of the OR is the same as for SAQ-7 and EQ-5D: e.g. the OR for RDS at baseline was 0.68, indicating that higher BMI is associated with worse dyspnea (not lower RDS score).

With adjustment of baseline covariates: age, sex, hypertension, diabetes, current smoker, atrial fibrillation, prior MI or prior PCI or prior CABG, prior heart failure, ejection fraction, prior stroke, peripheral artery disease, baseline Seattle Angina Questionnaire Summary Score, Canadian Cardiovascular Society Angina (I/II/III), New York Heart Association I/II/III, baseline low density lipoprotein- and high-density lipoprotein-cholesterol.

Follow-up health status associations also include adjustment for baseline health status.

Association between body mass index (BMI) and angina-related health status measure allowing for non-linearity.