Figure 3.

Performance on the testing variant (20:80) of the Go-No-Go (GNG) task. A) Percentages of testing day 1 false alarms across ages were significantly modified by genotype, primarily driven by significantly higher rates among 3xTg mice at 3 months old. Genotype interactions were not detected across other testing day 1 measures, although we did detect a significant decrease in B) hit percentages and C) sensitivity index scores among 3xTg mice at 9 months old. D) Genotype interactions were not detected on testing day 2 false alarm percentages, but E) hit percentages and F) sensitivity index scores across ages were significantly modified by genotype, primarily driven by significantly higher values among 3xTg mice at 3 months old. G) Genotype interactions were not detected on testing day 3 false alarm percentages. H) Percentages of testing day 3 hits were significantly modified by genotype, primarily driven by significantly higher and lower rates among 3xTg mice at 3 and 9 months old, respectively. I) Testing day 3 sensitivity scores were significantly modified by genotype, primarily driven by significantly lower values at 9 months old. Differences in performance across ages as a function of genotype were assessed with mixed-model analyses of variance, and one-way analyses of variance were used to directly compare genotypes at each age. *p < .05; **p < .01.