Figure 1.

The history of drug development. For a long time in the history of mankind, the era of crude drugs continued. In the 20th century, methods for purifying components from natural products were established. About 30 years ago, proteins such as antibodies and cytokines began to appear in the main products of pharmaceutical companies. Triggered by CAR-T cell therapy, which appeared in the 2010s, major pharmaceutical companies have entered the autologous cell medicine field one after another. In the near future, there will be a shift from the strategy of using autologous cells to the strategy of using allogeneic cells that have been endowed with some additional functions in advance as a universal, off-the-shelf cell medicine.