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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Clin Immunol. 2023 Oct 16;257:109809. doi: 10.1016/j.clim.2023.109809

Table 2.

Subtype-Specific anti-HIV bNAb Resistance.

bNAb Env Target
Domain
HIV bNAb Resistance A.A. mutation Ref.
3BNC117 and VRC01 CD4bs 30% subtype C viruses G458Y [235]
2G12, 10–1074 and PGT121 V3-glycan 96% CRF07_BC recombinant viruses and 40% subtype A viruses Deletion of N332 [51,235]
PG9 and PG16 V1/V2-glycan 100% of CRF01_AE recombinant Deletion of N160 [236]
CAP256.VRC26 V1/V2-glycan 85% subtype B viruses E/D164 substitution [218]