Table 2.
Subtype-Specific anti-HIV bNAb Resistance.
| bNAb | Env Target Domain |
HIV bNAb Resistance | A.A. mutation | Ref. |
|---|---|---|---|---|
| 3BNC117 and VRC01 | CD4bs | 30% subtype C viruses | G458Y | [235] |
| 2G12, 10–1074 and PGT121 | V3-glycan | 96% CRF07_BC recombinant viruses and 40% subtype A viruses | Deletion of N332 | [51,235] |
| PG9 and PG16 | V1/V2-glycan | 100% of CRF01_AE recombinant | Deletion of N160 | [236] |
| CAP256.VRC26 | V1/V2-glycan | 85% subtype B viruses | E/D164 substitution | [218] |