Table 1.
Characteristics of participants according to HIVDB GSS (>20% threshold)
| Characteristics | 0<GSS#<=2.75 | GSS#=3 | p-value$ | Total |
|---|---|---|---|---|
| N= 96 | N= 1284 | N= 1380 | ||
| Gender | 0.992 | |||
| Female | 15 (15.6%) | 201 (15.7%) | 216 (15.7%) | |
| Race | 0.258 | |||
| Asian | 7 (7.3%) | 90 (7.0%) | 97 (7.0%) | |
| Black | 10 (10.4%) | 246 (19.2%) | 256 (18.6%) | |
| White | 57 (59.4%) | 724 (56.4%) | 781 (56.6%) | |
| Hispanic | 18 (18.8%) | 199 (15.5%) | 217 (15.7%) | |
| Other | 4 (4.2%) | 36 (2.8%) | 40 (2.9%) | |
| Mode of HIV transmission | 0.553 | |||
| Heterosexual contacts | 19 (19.8%) | 327 (25.5%) | 346 (25.1%) | |
| PWID | 1 (1.0%) | 19 (1.5%) | 20 (1.4%) | |
| MSM | 73 (76.0%) | 886 (69.0%) | 959 (69.5%) | |
| Other/unknown | 3 (3.1%) | 52 (4.0%) | 55 (4.0%) | |
| Region of enrollment | <.001 | |||
| Africa | 3 (3.1%) | 136 (10.6%) | 139 (10.1%) | |
| Asia | 7 (7.3%) | 78 (6.1%) | 85 (6.2%) | |
| Australia | 5 (5.2%) | 40 (3.1%) | 45 (3.3%) | |
| Europe | 29 (30.2%) | 567 (44.2%) | 596 (43.2%) | |
| South America | 46 (47.9%) | 309 (24.1%) | 355 (25.7%) | |
| USA | 6 (6.3%) | 154 (12.0%) | 160 (11.6%) | |
| Age, years | 0.884 | |||
| Median (IQR) | 35 (28, 47) | 35 (28, 43) | 35 (28, 44) | |
| CD4 count, cells/mm3 | 0.177 | |||
| Median (IQR) | 654 (588, 730) | 632 (575, 721) | 633 (575, 721) | |
| HIV-RNA, log10 copies/mL | 0.630 | |||
| Median (IQR) | 4.45 (4.00, 4.79) | 4.48 (4.01, 4.86) | 4.47 (4.01, 4.86) | |
| CD4/CD8 ratio | 0.208 | |||
| Median (IQR) | 0.6 (0.5, 0.9) | 0.6 (0.4, 0.8) | 0.6 (0.4, 0.8) | |
| HBsAg, n(%) | 2 (2.1%) | 34 (2.7%) | 0.720 | 36 (2.7%) |
| HCVAb, n(%) | 1 (1.1%) | 36 (2.9%) | 0.299 | 37 (2.7%) |
| BMI, Kg/m2 | 0.645 | |||
| Median (IQR) | 23.8 (22.0, 26.6) | 24 (22, 27) | 24 (22, 27) | |
| Calendar year of starting ART | ||||
| Median (IQR) | 2012 (2011,2013) | 2012 (2011,2013) | 0.55 | 2012 (2011,2013) |
| Months from HIV diagnosis to enrolment | 0.015 | |||
| Median (IQR) | 8 (3, 22) | 11 (4, 31) | 10 (4, 30) | |
| Months from GRT* test to start of ART | 0.286 | |||
| Median (IQR) | 12 (2, 28) | 12 (3, 30) | 12 (3, 29) | |
| Co-morbidities, n(%) | ||||
| Cardiovascular disease | 2 (2.1%) | 8 (0.6%) | 0.104 | 10 (0.7%) |
| Diabetes | 2 (2.1%) | 37 (2.9%) | 0.649 | 39 (2.8%) |
| Dyslipidemia | 2 (2.1%) | 53 (4.1%) | 0.323 | 55 (4.0%) |
| Hypertension | 7 (7.3%) | 125 (9.7%) | 0.433 | 132 (9.6%) |
$
Chi-square or Mann-Whitney U as appropriate
#
HIVDB v8.6 with >20% threshold
*
Genotypic Resistance Test