Table 2:
Hazard ratios and 95% confidence intervals for the risk of developing cervical pre-cancer and cancer.
| Moderate dysplasia | Severe dysplasia | Carcinoma in situ | Cervical cancer | |||||
|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable* | Univariable | Multivariable* | Univariable | Multivariable* | Univariable | Multivariable* | |
|
| ||||||||
| HIV status | ||||||||
| Negative | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Positive | 5.31 (4.94– 5.70) | 3.57 (3.30–3.87) | 5.15 (4.79– 5.54) | 3.32 (3.06–3.60) | 4.82 (4.10– 5.67) | 2.90 (2.42–3.47) | 3.56 (2.93–4.32) | 2.99 (2.40–3.73) |
| Age group | ||||||||
| 18–24 | 0.35 (0.30– 0.41) | 0.48 (0.41–0.56) | 0.23 (0.19– 0.28) | 0.32 (0.27–0.38) | 0.27 (0.18– 0.39) | 0.38 (0.26–0.55) | 0.04 (0.01–0.13) | 0.06 (0.02–0.17) |
| 25–34 | 1.13 (1.04– 1.22) | 1.24 (1.15–1.34) | 0.99 (0.91– 1.07) | 1.08 (0.99–1.17) | 0.86 (0.72– 1.04) | 0.93 (0.77–1.13) | 0.30 (0.21–0.42) | 0.32 (0.22–0.46) |
| 35–44 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 45–54 | 0.45 (0.41– 0.50) | 0.52 (0.47–0.58) | 0.53 (0.48– 0.59) | 0.62 (0.56–0.68) | 0.65 (0.53– 0.81) | 0.78 (0.63–0.96) | 1.59 (1.27–1.99) | 1.83 (1.45–2.30) |
| 55–64 | 0.16 (0.14– 0.20) | 0.22 (0.19–0.27) | 0.25 (0.21– 0.28) | 0.33 (0.29–0.39) | 0.32 (0.24– 0.44) | 0.46 (0.34–0.63) | 1.49 (1.16–1.91) | 1.99 (1.54–2.57) |
| ≥65 | 0.05 (0.04– 0.07) | 0.08 (0.06–0.11) | 0.05 (0.03– 0.07) | 0.08 (0.06–0.11) | 0.21 (0.14– 0.31) | 0.39 (0.26–0.57) | 1.31 (1.00–1.71) | 2.09 (1.56–2.79) |
| Calendar year | ||||||||
| 2011–2013 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 2014–2016 | 1.22 (1.15– 1.29) | 1.05 (0.96–1.15) | 1.19 (1.09– 1.29) | 1.07 (0.98–1.18) | 0.98 (0.81– 1.20) | 0.92 (0.75–1.12) | 0.96 (0.76–1.20) | 1.11 (0.88–1.41) |
| 2017–2020 | 1.20 (1.13– 1.28) | 1.04 (0.95–1.14) | 1.07 (0.99– 1.16) | 1.00 (0.91–1.10) | 0.92 (0.76– 1.12) | 0.87 (0.72–1.06) | 0.88 (0.70–1.10) | 1.05 (0.83–1.32) |
| History of genital warts | ||||||||
| No | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Yes | 14.13 (12.16–16.42) | 5.33 (4.56–6.22) | 10.50 (8.84–12.47) | 4.16 (3.49–4.96) | 12.68 (9.05–17.77) | 5.33 (3.75–7.58) | 4.40 (2.35–8.25) | 2.97 (1.56–5.64) |
| History of other sexually transmitted infections | ||||||||
| No | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Yes | 3.14 (2.69– 3.68) | 1.41 (1.20–1.66) | 2.79 (2.36– 3.30) | 1.30 (1.10–1.55) | 3.37 (2.39– 4.74) | 1.63 (1.15–2.31) | 2.89 (1.90–4.41) | 2.33 (1.52–3.60) |
| History of oral contraceptive use | ||||||||
| No | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Yes | 1.97 (1.76– 2.21) | 1.33 (1.18–1.50) | 1.60 (1.41– 1.82) | 1.21 (1.06–1.37) | 1.49 (1.12– 1.99) | 1.31 (0.98–1.77) | 0.43 (0.24–0.77) | 0.82 (0.46–1.47) |
*
The multivariable model adjusts for all risk factors listed in the table and population group (Black African, White, Other, Missing)