FIGURE 4:

The percentage of area occupied by total tau and transactive response DNA-binding protein 43 (TDP-43) immunoreactivity across cohorts. The mean total percentage of immunoreactivity (sum of AT8 and TDP-43 positivity) is shown across all hippocampal subregions in all groups, where dark purple bars represent the proportion of TDP-43 immunoreactivity relative to total burden in the AD/TDP group. (A) In the CA1, AD/TDP and AD showed nearly equivalent total immunoreactivity, primarily due to an abundance of tau pathology. (B, C) In the CA3 and dentate gyrus (DG), AD/TDP showed significantly greater total immunoreactivity compared with AD and FTLD-TDP groups, also determined by high relative burden of tau pathology. Within the AD/TDP group, TDP-43 immunoreactivity comprised a minimal proportion of total pathology. Bars represent mean percentage of area occupied by total immunoreactivity and standard error is shown. Note, dark purple bar in AD/TDP is not to scale. *p < 0.05; **p < 0.01; data analyses excluding GRN (FTLD-TDP type A) and FTLD-TDP type C are not shown”.