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. Author manuscript; available in PMC: 2024 Feb 16.
Published in final edited form as: Environ Int. 2023 Oct 17;181:108270. doi: 10.1016/j.envint.2023.108270

Table 2.

FDR-corrected significantly differentially methylated CpG sites by air pollutants.a,b

Associated pollutant Probe Mapped gene Chr Relation to CpG island Black
 NHW
Effect estimate 95 % CI P-value Effect estimate 95 % CI P-value
NO2 cg24537688 – 2 −0.006 (−0.039, 0.027) 0.725 −0.049 (−0.066, −0.031) 8.47E-08
cg24269657 F7 13 North shore −0.118 (−0.159, −0.077) 2.90E-08 0.012 (−0.015, 0.039) 0.373
PM2.5 cg07635198 PRPF40A 2 −0.115 (−0.154, −0.076) 1.11E-08 0.014c (−0.017, 0.045) 0.370
cg08097847 ZCCHC24 10 North shore 0.207 (0.136, 0.278) 1.76E-08 −0.061c (−0.124, 0.001) 0.055
cg01593570 MARCH10 17 −0.133 (−0.182, −0.084) 1.18E-07 −0.009c (−0.046, 0.029) 0.643
cg13538431 RP11–1252I4.2;RP11–423H2.1;RP11–423H2.3 5 −0.164 (−0.225, −0.103) 2.00E-07 0.027c (−0.020, 0.074) 0.261
cg23717809 RP11–510 M2.1 16 South shore −0.114 (−0.157, −0.071) 2.44E-07 −0.030c (−0.070, 0.010) 0.143
cg06738602 PTGER2 14 North shore 0.185 (0.115, 0.256) 3.05E-07 −0.008 (−0.053, 0.036) 0.711
cg00212245 – 8 −0.103 (−0.142, −0.063) 3.73E-07 −0.011c (−0.042, 0.019) 0.465
cg01906102 SSX1; SSX5 X −0.121 (−0.168, −0.074) 4.89E-07 0.004 (−0.022, 0.030) 0.761
cg04902542 TBC1D16 17 North shelf −0.077 (−0.106, −0.047) 5.00E-07 0.007 (−0.009, 0.024) 0.361
cg05411829 – 16 −0.088 (−0.122, −0.054) 5.08E-07 −0.004 (−0.022, 0.013) 0.615
cg08052751 SETBP1 18 −0.128 (−0.177, −0.078) 5.92E-07 −0.002c (−0.039, 0.034) 0.907
cg11514293 GALC 14 −0.093 (−0.129, −0.056) 8.01E-07 0.005c (−0.026, 0.035) 0.762
cg10011083 VOPP1 7 Island 0.173 (0.104, 0.241) 9.71E-07 −4.87E-04 (−0.026, 0.025) 0.971
cg16722016 – 12 −0.125 (−0.175, −0.075) 1.02E-06 −1.58E-05c (−0.038, 0.038) 0.999
cg18580650 – 5 North shelf −0.083 (−0.116, −0.050) 1.08E-06 −0.014 (−0.030, 0.002) 0.085
cg11130461 ZBTB20 3 Island −0.161 (−0.225, −0.097) 1.10E-06 −0.003 (−0.062, 0.056) 0.931
cg24544356 FSTL5 4 −0.087 (−0.122, −0.053) 1.15E-06 −0.010c (−0.041, 0.021) 0.528
cg17608585 RP11–1055B8.3 17 North shore −0.114 (−0.160, −0.069) 1.23E-06 0.016c (−0.018, 0.050) 0.356
[a]

Survey-weighted generalized linear regression models were performed separately by race/ethnicity subgroup. Models adjusted for Houseman cell type proportions, chronological age, education, BMI, physical activity, smoking status, cigarette pack-years, region, and ADI at the census block group level.

[b]

CpG sites that were significant for at least one of the race/ethnicity subgroups are presented for both subgroups, for comparison.

[c]

Effect estimates, CIs, and p-values for probes that were not meta-analyzed among NHW participants are from the EWAS of EPIC probes only (n=1311). Abbreviations: ADI, area deprivation index; BMI, body mass index; Chr, chromosome; CI, confidence interval; CpG, Cytosine-phosphate-Guanine; FDR, false discovery rate; NHW, non-Hispanic White; NO2, nitrogen dioxide; PM2.5, particulate matter<2.5 μm in diameter.