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Factors influencing the likelihood of romiplostim response in CIT.
| Response Less Likely | Response More Likely |
|---|---|
| Bone marrow infiltration by tumor | Solid tumor with no bone metastasis |
| Dramatic elevations of endogenous thrombopoietin (>10–20 times upper limit of normal) | Normal or modest elevation (<5 times upper limit of normal) of endogenous thrombopoietin |
| Prior temozolomide treatment | |
| Prior pelvic irradiation | |
| Diffuse bone metastases | |
| Lymphoid malignancy involving bone marrow |
