Table 2.

List of LSD1 inhibitors in combination with other anticancer drugs.

S.No	LSD1 KD/ Inhibitor	Combination Drug	Class of drug combination	Indication	Ref
1	GSK-LSD1	Doxorubicin	Alkylant agent	Breast Cancer	86
		anti-PD-1	Immunotherapy	HCC	20
		AC1Q3QWB	HOTAIR-EZH2 Inhibitor	Glioblastoma	73
2.	Bomedemstat (IMG-7289)	anti-PD-1	Immunotherapy	Small Cell Lung Cancer	22
		Venetoclax	BCL-2 Inhibitor	HSC-derived leukemias	82
3.	SP2509	Panobinostat	HDAC inhibitor	Acute myeloid leukemia	67
		Tazemetostat	EZH2 Inhibitor	Acute myeloid leukemia	81
		Romidepsin	HDAC inhibitor	Ewing Sarcoma	66
		Etoposide	Topoisomerase II inhibitor	Ewing Sarcoma	66
		Verteporfin	YAP inhibitor	OSCC	19
		anti-PD-1	Immunotherapy	HNSCC, OSCC, TNBC	18, 19, 36
		JQ1	BET bromodomain inhibitor	CRPC	83
		Sulforaphane	HDAC inhibitor	Breast Cancer	68
		EPZ6438	EZH2 Inhibitor	Acute myeloid leukemia	81
		Docetaxel	Taxans	Prostate cancer	84
		Regorafenib	Multi-kinase inhibitor	HCC	91
4.	JBI-097	Dual inhibitor LSD1 Inhibitor	HDAC6, and Leukemia SCLC Melanoma HCC	Multiple Myeloma	62
5.	GSK2879552	anti-PD-1	Immunotherapy	Colorectal cancer Melanoma	35
		Sorafenib	Multikinase Inhibitor	HCC	92
		ATRA	Retinoids	Acute myeloid leukemia	74
6	ZY0511	DTP3	Vaccine	HCC	94
		5-fluorouracil	Anti-metabolites	Colorectal cancer	99
7	GSK690	JNJ-26481585	HDAC inhibitor	Rhabdomyosarcoma	69
8	Ex917	Vorinostat	HDAC inhibitor	Rhabdomyosarcoma	69
9	LSD1 KD	Vorinostat	HDAC inhibitor	Glioblastoma	71
		anti-PD-1	Immunotherapy	Melanoma,	23
		UVA radiation	Radiation	Skin Cancer	52
10	Tranylcypromine	Vorinostat	HDAC inhibitor	Glioblastoma	71,72
		ATRA	Retinoids	Acute myeloid leukemia	75
	Tranylcypromine (Compound 7)	Dual inhibitor	HDAC1/2, and LSD1 Inhibitor	Gastric cancer, Breast cancer, Colorectal cancer, Lung cancer, Prostate cancer	61
	OG-86 (Tranylcypromin e -derivatives)	RAD001	mTOR Inhibitor	Acute myeloid leukemia	79
11	ORY-1001	anti-PD-1	Immunotherapy	SCLC	21
		anti-CD47/PD-L1	Immunotherapy	Cervical Cancer	30
		Ruxolitinib	JAK inhibitor	Acute myeloid leukemia	78
		I-BET-762	BET inhibitor	CRPC	83
12	NCD38	Temozolomide	Alkylant agent	Glioblastoma	45
		Rapamycin	mTOR Inhibitor	Endometrial cancer	88
13	Compound 5	Dual inhibitor	HDAC/LSD1 Inhibitor	Gastric cancer	64
14	Corin	Dual inhibitor	HDAC/LSD1 Inhibitor	DIPG	65
15	Pargyline	Vorinostat	HDAC inhibitor	TNBC	70
		Enzalutamide	Androgen Receptor Inhibitor	Kidney Cancer	97
16	MC_2580 DDP_38003	ATRA	Retinoids	Acute myeloid leukemia	76
17	INCB059872	OTX-015	BET inhibitor	Acute myeloid leukemia	77
18	Clorgyline	5-Aza-CdR	DNMT inhibitor	Bladder Cancer	98