Table 2-.
Univariable and Multivariable Analysis of Overall Survival in Patients who Received Chemotherapy
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Characteristic (Reference) | HR1 | 95% CI1 | p-value | HR1 | 95% CI1 | p-value |
|
| ||||||
| Age | 1.06 | 1.04, 1.07 | <.001 | 1.05 | 1.04, 1.06 | <.001 |
| Sex (Male) | ||||||
| Female | 1.11 | 0.82, 1.49 | .49 | — | — | — |
| Race (White) | ||||||
| Black | 0.98 | 0.40, 2.40 | .97 | — | — | — |
| Other/Unknown | 0.99 | 0.44, 2.23 | .97 | — | — | — |
| Asian/Pacific Islander | 0.56 | 0.18, 1.75 | .32 | — | — | — |
| Charlson-Deyo Comorbidity Index (0) | ||||||
| 1 | 2.01 | 1.35, 3.00 | <.001 | 1.83 | 1.22, 2.74 | .004 |
| 2 or more | 3.11 | 1.99, 4.86 | <.001 | 2.72 | 1.71, 4.31 | <.001 |
| Grade (2) | ||||||
| 3 | 3.01 | 2.09, 4.35 | <.001 | 3.28 | 2.25, 4.79 | <.001 |
| Extent of Resection (No surgery/Subtotal) | ||||||
| Gross-total resection | 0.66 | 0.48, 0.91 | .01 | 0.63 | 0.46, 0.88 | .006 |
| Radiation (No) | ||||||
| Yes | 1.72 | 1.08, 2.72 | .02 | 1.31 | 0.82, 2.08 | .26 |
| MGMT (Methylated) | ||||||
| Unmethylated | 2.07 | 1.51, 2.85 | <.001 | 2.61 | 1.89, 3.60 | <.001 |
1
HR = Hazard Ratio, CI = Confidence Interval
Bold is statistically significant.