Figure 1.
Schematic diagram of Piezo1 Channel activation by mechanical force. The Piezo1 channel is a trimeric structure located in the plasma membrane. The mechanical force exerted on the cytoskeleton and extracellular matrix (ECM) causes the opening of the Piezo1 channel, leading to the influx of extracellular Ca2+ and transducing mechanical signals into electrical and chemical signals in the cell.