Table 2.

DAT1 rs6347*BDNF Val66Met interactions on Aβ-PET (A), (B), entorhinal tau-PET (C), (D), and meta-temporal lobe tau-PET (E), (F).

Variable	Unstandardized Coef.	SE	t	p	95% CI

(A) Aβ-PET (cross-sectional)		R² = .070, F(6, 314) = 3.914, p = .0009

rs6347*Val66Met	12.273	5.219	2.352	.019	2.004, 22.542
rs6347	−3.121	2.528	−1.235	.218	−8.095, 1.852
Val66Met	−5.012	3.527	−1.421	.156	−11.951, 1.927
Sex	4.155	3.471	1.197	.232	−2.675, 10.985
Age	.943	.245	3.845	.0001	.460, 1.425
Years Ed	−.586	.749	−.783	.434	−2.059, .887
(B) Aβ-PET (longitudinal)		R² = .048, F(8, 226) = 3.914, p = .188
rs6347*Val66Met	.861	.473	1.691	.092	−.133, 1.737
rs6347	−.257	.229	−1.119	.265	−.710, .196
Val66Met	−.023	.315	−.074	.942	−.645, .598
Sex	.358	.316	1.131	.259	−.266, .981
Age	.060	.024	2.470	.041	.012, .108
Years Ed	−.033	.067	−.493	.622	−165, .108
Follow-up Time	−.106	.154	−.689	.492	−.410, .198
Number of scans	.060	.322	.185	.853	−.575, .695
(C) Entorhinal tau-PET (cross-sectional)		R² = .058, F(6, 314) = 3.247, p = .004
rs6347*Val66Met	.055	.022	2.493	.013	.012, .098
rs6347	−.018	.011	−1.669	.096	−.039, .003
Val66Met	−.025	.015	−1.703	.090	−.055, .004
Sex	.005	.015	.328	.743	−.024, .034
Age	.002	.001	1.759	.080	−.0002, .004
Years Ed	.007	.003	2.115	.035	.0005, .013
(D) Entorhinal tau-PET slope		R² = .201, F(8, 126) = 3.956, p = .0003
rs6347*Val66Met	.012	.003	3.437	.0008	.005, .017
rs6347	−.003	.001	−1.988	.049	−.006, −.001
Val66Met	−.002	.002	−.737	.463	−.006, .003
Sex	.003	.002	1.232	.220	−.002, .007
Age	.0003	.0002	1.928	.056	.00002 .001
Years Ed	.001	.0004	1.129	.199	−.0003, .001
Follow-up Time	−.001	.001	−1.663	.099	−.003, .0003
Number of scans	.003	.001	2.063	.041	.0001, .006
(E) Meta-temporal tau-PET (cross-sectional)		R² = .056, F(6, 314) = 3.108, p = .006
rs6347*Val66Met	.067	.020	3.344	.0009	.028, .106
rs6347	−.017	.010	−1.722	.086	−.036, .002
Val66Met	−.010	.014	−.756	.450	−.037, .016
Sex	−.0006	.013	−.046	.964	−.027, .026
Age	.002	.0009	1.455	.147	−.0005, .003
Years Ed	.004	.003	1.355	.176	−.002, .010
(F) Meta-temporal tau-PET slope		R² = .122, F(8, 126) = 2.181, p = .033
rs6347*Val66Met	.014	.004	3.265	.001	.006, .023
rs6347	−.003	.002	−1.274	.205	−.007, .001
Val66Met	−.001	.003	−.232	.817	−.006, .005
Sex	.0001	.003	.281	.794	−.001, .001
Age	.0001	.0002	.505	.614	−.0003, .001
Years Ed	.0001	.001	.228	.820	−.001, .001
Follow-up Time	−.001	.001	−.811	.419	−.003, .001
Number of scans	.003	.002	1.476	.143	−.001, .007