Table 3.

Associations between continuous antibody titers and whole-brain cortical thickness

	Model 1		Model 2		Model 3
Pathogen	Beta estimate	P- value	Beta estimate	P- value	Beta estimate	P- value
HSV-1	−2.79	0.282	−2.63	0.309	−2.64	0.302
HSV-2	−3.11	0.0460	−3.20	0.0397	−3.07	0.0475
Cytomegalovirus	−2.84	0.378	−2.27	0.486	−1.38	0.672
C. pneumoniae	−4.25	0.0418	−4.02	0.0532	−3.55	0.0875
H. pylori	−0.0572	0.595	−0.0270	0.802	−0.0494	0.645
Infectious Burden Index	−9.82	0.462	−8.58	0.518	−6.13	0.644

Model 1: Adjusted for age at MRI, gender, ethnicity, and high school education

Model 2: Adjusted for age at MRI, gender, ethnicity, high school education, and hypertension, diabetes, hypercholesterolemia, and smoking at the time of imaging

Model 3: Adjusted for age at MRI, gender, race-ethnicity, high school education, and hypertension, diabetes, hypercholesterolemia, and smoking at the time of imaging, prior subclinical infarction, logarithmic white matter hyperintensity volume, total volume of small perivascular spaces, and total cranial volume