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. Author manuscript; available in PMC: 2025 Apr 1.
Published in final edited form as: Int J Cancer. 2023 Nov 15;154(7):1174–1190. doi: 10.1002/ijc.34794

Table 3.

Cholelithiasis and biliary tract cancer mortality and incidence.

Site Cases HR1 95% CI HR2 95% CI HR3 95% CI
Mortality
Males
 Biliary Tract Cancer 574 1.40 (0.97 -2.00) 1.39 (0.97 -1.99) 1.23 (0.82 -1.83)
 total Biliary Tract Cancer 538 1.34 (0.94 -1.93) 1.36 (0.95 -1.95) 1.21 (0.81 -1.80)
 Intrahepatic bile duct 92 1.69 (0.73 -3.90) 1.69 (0.73 -3.90) 1.84 (0.79 -4.26)
 Gallbladder 113 0.98 (0.40 -2.41) 0.98 (0.40 -2.41) 0.67 (0.21 -2.11)
 Extrahepatic bile duct 341 1.43 (0.93 -2.21) 1.43 (0.92 -2.21) 1.25 (0.77 -2.03)
Females
 Biliary Tract Cancer 628 3.00 (2.45 -3.66) 2.99 (2.44 -3.66) 2.94 (2.39 -3.63)
 total Biliary Tract Cancer 469 2.67 (2.06 -3.46) 2.68 (2.06 -3.48) 2.60 (1.97 -3.43)
 Intrahepatic bile duct 57 2.92 (1.42 -6.01) 3.00 (1.45 -6.20) 3.12 (1.51 -6.45)
 Gallbladder 183 3.08 (2.07 -4.59) 3.12 (2.09 -4.67) 2.89 (1.87 -4.49)
 Extrahepatic bile duct 230 2.40 (1.64 -3.51) 2.37 (1.61 -3.50) 2.37 (1.58 -3.56)
Incidence
Males
 Biliary Tract Cancer 839 1.34 (0.99 -1.81) 1.33 (0.98 -1.79) 1.25 (0.90 -1.73)
 total Biliary Tract Cancer 430 1.82 (1.24 -2.67) 1.81 (1.23 -2.65) 1.62 (1.06 -2.46)
 Intrahepatic bile duct 122 1.78 (0.82 -3.85) 1.76 (0.81 -3.82) 1.37 (0.55 -3.39)
 Gallbladder 201 1.33 (0.74 -2.40) 1.34 (0.74 -2.41) 1.25 (0.66 -2.37)
 Extrahepatic bile duct 505 1.17 (0.79 -1.73) 1.15 (0.78 -1.71) 1.09 (0.71 -1.67)
Females
 Biliary Tract Cancer 856 2.62 (2.19 -3.14) 2.63 (2.19 -3.15) 2.57 (2.13 -3.11)
 total Biliary Tract Cancer 521 2.94 (2.35 -3.68) 2.92 (2.33 -3.67) 2.82 (2.23 -3.58)
 Intrahepatic bile duct 66 3.14 (1.52 -6.46) 3.22 (1.56 -6.64) 2.88 (1.34 -6.18)
 Gallbladder 396 3.21 (2.51 -4.10) 3.23 (2.52 -4.14) 3.28 (2.53 -4.26)
 Extrahepatic bile duct 416 2.13 (1.61 -2.82) 2.10 (1.58 -2.79) 1.97 (1.45 -2.66)

HR1, Adjusted for BMI and age; HR2, Adjusted for BMI, age, education, population density, marriage status, past history of CHD, stroke, DM, hypertension, smoking status and alchol drinking status.; HR3, Excluded early cases and adjusted for the same variables as HR2.

Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio