Table 4.
Total, direct, and indirect effects of BMI for the risk of biliary tract cancer mortality.
| Model 1 | Model 2 | Model 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | ||||||
| Males | |||||||||||
| Biliary Tract Cancer | |||||||||||
| Total effect | 1.16 | (0.94 | -1.44) | 1.16 | (0.93 | -1.44) | 1.14 | (0.91 | -1.43) | ||
| Direct effect | 1.16 | (0.93 | -1.43) | 1.15 | (0.93 | -1.43) | 1.14 | (0.91 | -1.42) | ||
| Indirect effect | 1.00 | (1.00 | -1.01) | 1.00 | (1.00 | -1.01) | 1.00 | (1.00 | -1.01) | ||
| total Biliary Tract Cancer | |||||||||||
| Total effect | 1.08 | (0.87 | -1.34) | 1.06 | (0.86 | -1.31) | 1.06 | (0.85 | -1.31) | ||
| Direct effect | 1.08 | (0.87 | -1.33) | 1.05 | (0.85 | -1.30) | 1.05 | (0.84 | -1.31) | ||
| Indirect effect | 1.01 | (1.00 | -1.01) | 1.01 | (1.00 | -1.01) | 1.00 | (1.00 | -1.01) | ||
| Intrahepatic bile duct | |||||||||||
| Total effect | 1.14 | (0.66 | -1.96) | 1.10 | (0.65 | -1.88) | 1.27 | (0.69 | -2.33) | ||
| Direct effect | 1.13 | (0.65 | -1.94) | 1.09 | (0.64 | -1.86) | 1.25 | (0.68 | -2.30) | ||
| Indirect effect | 1.01 | (0.99 | -1.03) | 1.01 | (0.99 | -1.03) | 1.01 | (0.99 | -1.03) | ||
| Gallbladder | |||||||||||
| Total effect | 0.76 | (0.53 | -1.08) | 0.73 | (0.52 | -1.02) | 0.77 | (0.53 | -1.11) | ||
| Direct effect | 0.76 | (0.53 | -1.08) | 0.73 | (0.52 | -1.01) | 0.76 | (0.53 | -1.11) | ||
| Indirect effect | 1.00 | (0.99 | -1.01) | 1.00 | (0.99 | -1.01) | 1.00 | (0.99 | -1.01) | ||
| Extrahepatic bile duct | |||||||||||
| Total effect | 1.24 | (0.93 | -1.67) | 1.24 | (0.92 | -1.66) | 1.16 | (0.86 | -1.55) | ||
| Direct effect | 1.23 | (0.92 | -1.66) | 1.23 | (0.91 | -1.65) | 1.15 | (0.86 | -1.55) | ||
| Indirect effect | 1.01 | (1.00 | -1.02) | 1.01 | (1.00 | -1.02) | 1.00 | (1.00 | -1.01) | ||
| Females | |||||||||||
| Biliary Tract Cancer | |||||||||||
| Total effect | 1.25 | (1.02 | -1.54) | 1.28 | (1.03 | -1.58) | 1.25 | (1.01 | -1.56) | ||
| Direct effect | 1.20 | (0.98 | -1.47) | 1.23 | (1.00 | -1.52) | 1.21 | (0.98 | -1.50) | ||
| Indirect effect | 1.04 | (1.02 | -1.06) | 1.04 | (1.02 | -1.05) | 1.03 | (1.02 | -1.05) | ||
| total Biliary Tract Cancer | |||||||||||
| Total effect | 1.48 | (1.13 | -1.94) | 1.45 | (1.11 | -1.89) | 1.44 | (1.09 | -1.90) | ||
| Direct effect | 1.44 | (1.11 | -1.89) | 1.41 | (1.08 | -1.84) | 1.41 | (1.07 | -1.86) | ||
| Indirect effect | 1.02 | (1.00 | -1.05) | 1.02 | (1.01 | -1.04) | 1.02 | (1.00 | -1.04) | ||
| Intrahepatic bile duct | |||||||||||
| Total effect | 2.85 | (0.97 | -8.39) | 2.40 | (0.88 | -6.49) | 2.56 | (0.91 | -7.26) | ||
| Direct effect | 2.82 | (0.96 | -8.30) | 2.36 | (0.88 | -6.36) | 2.52 | (0.90 | -7.10) | ||
| Indirect effect | 1.01 | (0.95 | -1.08) | 1.02 | (0.96 | -1.08) | 1.02 | (0.96 | -1.08) | ||
| Gallbladder | |||||||||||
| Total effect | 1.81 | (1.12 | -2.94) | 1.67 | (1.05 | -2.65) | 1.51 | (0.95 | -2.40) | ||
| Direct effect | 1.71 | (1.07 | -2.73) | 1.58 | (1.01 | -2.47) | 1.45 | (0.93 | -2.28) | ||
| Indirect effect | 1.06 | (1.01 | -1.11) | 1.06 | (1.01 | -1.11) | 1.04 | (1.00 | -1.08) | ||
| Extrahepatic bile duct | |||||||||||
| Total effect | 1.12 | (0.81 | -1.55) | 1.16 | (0.82 | -1.62) | 1.20 | (0.84 | -1.72) | ||
| Direct effect | 1.12 | (0.81 | -1.54) | 1.15 | (0.82 | -1.61) | 1.19 | (0.83 | -1.72) | ||
| Indirect effect | 1.00 | (0.98 | -1.02) | 1.00 | (0.98 | -1.02) | 1.01 | (0.99 | -1.03) | ||
Model 1, Adjusted for age and cohort; Model 2, Adjusted for age, cohort, education, population density, marriage status, past history of CHD, stroke, DM, hypertension, smoking status and alchol drinking status.
Abbreviations: CI, confidence interval; HR, hazard ratio