. Author manuscript; available in PMC: 2024 Nov 1.

Published in final edited form as: Mult Scler Relat Disord. 2023 Aug 28;79:104964. doi: 10.1016/j.msard.2023.104964

Table 3.

Results for 2-Sample MR Univariate Analyses of Non-Overlapping Instruments

Exposure	Number of Variants	Method	Beta	SE	p-value	MR-PRESSO
Exposure	Number of Variants	Method	Beta	SE	p-value	p(Global)	p(Outlier)	p(Distortion)
BMI	502	Inverse-variance Weighted	0.283	0.070	<0.001	<0.001	<0.001	0.527
WHR	227	Inverse-variance Weighted	−0.016	0.137	0.907	<0.001	0.313	0.336
VAT	130	Inverse-variance Weighted	0.282	0.104	0.007	<0.001	<0.001	0.562
AFR	7	Inverse-variance Weighted	0.238	0.422	0.573	0.006	0.067	0.473
LFR	1	Wald Ratio	−0.197	0.663	0.766	NA	NA	NA
TFR	6	Inverse-variance Weighted	0.127	0.475	0.505	0.048	NA	NA