Table 2.

Statistics of CASP assembly rounds over the years, including the share of heteromeric targets, the number of targets having more than two chains, difficulty class shares, number of targets shared with the joint CAPRI round, maximum ICS profiles acquired for the hard targets, number of competitors and total number of models submitted, the top performing approaches.

CASP Round	No. of targets (heteromers/all)	No. of target more than two chains	Difficulty (easy/medium/hard)	No. of shared targets with CAPRI	Maximum ICS observed for hard targets	No. of groups/No. of models	Notable approaches
CASP12	8/30	14	9/6/15	15	0.15	108/1600	Homology modeling
CASP13	12/42	17	12/17/13	20	0.52	45/5000	Homology modeling
CASP14	17/22	13	2/20/6	12	0.48	39/2500	Homology modeling Docking DL-based contacts Fold-and-dock
CASP15	20/40	17	14/22/4	36	0.95	87/11,000	Mainly AF2-M based modeling