Table 4.
ΔICS values for each target, the best ICS of NBIS-AF2-M, the best ICS generated and its source group, and the communities’ performance assessment.
| Target ID | NBIS-AF2-M ICS | The best ICS | The best ICS model’s group | ΔIC S | Community and NBIS-AF2-M performed well | Nobody performed well | Community performed well | The reason of NBIS-AF2-M failure |
|---|---|---|---|---|---|---|---|---|
| H1106 | 0.80 | 0.84 | OpenFold | 0.03 | x | |||
| H1111 | 0.04 | 0.61 | Yang-Multimer | 0.57 | x | technical limitation | ||
| H1114 | 0.17 | 0.84 | Yang | 0.67 | x | technical limitation | ||
| H1114v2 | 0.38 | 0.62 | Venclovas | 0.24 | x | technical limitation | ||
| H1129 | 0.08 | 0.76 | Wallner | 0.67 | x | wrong interface | ||
| H1134 | 0.69 | 0.81 | Wallner | 0.12 | x | |||
| H1135 | 0.38 | 0.68 | UltraFold | 0.30 | x | wrong interface | ||
| H1137 | 0.66 | 0.83 | bio3d | 0.16 | x | |||
| H1140 | 0.10 | 0.81 | Wallner | 0.71 | x | Nanobody-antigen | ||
| H1141 | 0.09 | 0.80 | Zheng | 0.72 | x | nanobody-antigen | ||
| H1142 | 0.00 | 0.45 | Kiharalab | 0.45 | x | nanobody-antigen | ||
| H1143 | 0.92 | 0.92 | NBIS-AF2-multimer | 0.00 | x | |||
| H1144 | 0.09 | 0.74 | Zheng | 0.65 | x | nanobody-antigen | ||
| H1151 | 0.82 | 0.84 | Wallner | 0.02 | x | |||
| H1157 | 0.74 | 0.79 | Manifold-E | 0.05 | x | |||
| H1166v1 | 0.20 | 0.30 | Manifold-E | 0.09 | x | antibody-antigen | ||
| H1167v1 | 0.00 | 0.12 | ShanghaiTech | 0.12 | x | antibody-antigen | ||
| H1168v1 | 0.71 | 0.84 | DFolding-refine | 0.13 | x | |||
| H1171 | 0.58 | 0.62 | MultiFOLD | 0.04 | x | |||
| H1172 | 0.56 | 0.63 | Manifold-LC-E | 0.07 | x | |||
| H1185 | 0.70 | 0.72 | Yang | 0.03 | x | |||
| T1109o | 0.52 | 0.85 | Wallner | 0.33 | x | Mutation induced change | ||
| T1110o | 0.92 | 0.95 | ColabFold | 0.03 | x | |||
| T1113o | 0.79 | 0.93 | Manifold | 0.14 | x | |||
| T1115o | 0.18 | 0.68 | Venclovas | 0.50 | x | technical limitation | ||
| T1121o | 0.42 | 0.68 | DFolding-server | 0.25 | x | wrong interface | ||
| T1123o | 0.20 | 0.46 | MULTICOM_deep | 0.27 | x | viral protein/weak evolutionary signal | ||
| T1124o | 0.87 | 0.89 | MULTICOM | 0.02 | x | |||
| T1127o | 0.91 | 0.91 | NBIS-AF2-multimer | 0.00 | x | |||
| T1132o | 0.86 | 0.90 | BAKER | 0.04 | x | |||
| T1153o | 0.74 | 0.86 | MULTICOM_qa | 0.12 | x | |||
| T1160o | 0.16 | 0.57 | PEZYFoldings | 0.41 | x | Mutation induced change | ||
| T1161o | 0.36 | 0.92 | Wallner | 0.56 | x | Mutation induced change | ||
| T1170o | 0.57 | 0.65 | Yang | 0.08 | x | |||
| T1173o | 0.47 | 0.69 | Yang | 0.22 | x | |||
| T1174o | 0.81 | 0.90 | Manifold-E | 0.09 | x | |||
| T1178o | 0.64 | 0.72 | DFolding-server | 0.09 | x | |||
| T1179o | 0.16 | 0.81 | DFolding | 0.65 | x | wrong interface | ||
| T1181o | 0.49 | 0.63 | PEZYFoldings | 0.14 | x | |||
| T1187o | 0.00 | 0.95 | Venclovas | 0.95 | x | wrong interface | ||
| T1192o | 0.70 | 0.75 | Yang | 0.05 | x |