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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Physiol. 2023 Sep 29;601(21):4751–4766. doi: 10.1113/JP284238

Figure 2. NMDA microinjection in the SNpc increases the tone and motility of the proximal colon.

Figure 2.

A. Representative micrograph showing the location of a NMDA injection (arrow) in SNpc (Aa, scale bar: 500μm). Schematic image summarizing the location of the injections in SNpc (Ab, N=21).

B. Representative trace showing that the NMDA (5nmoles/210nl) microinjection in the left SNpc (arrow) increases both tone and motility of the proximal colon.

C. Summary graphic showing the increase in motility (N=21, p<0.0001, one tailed paired t test) and tone (N=21) of the proximal colon upon NMDA microinjection in the left SNpc.

D. Representative trace showing that the AMPA (5nmoles/210nl) microinjection in the left SNpc (arrow) increases both tone and motility of the proximal colon.

E. Summary graphic showing the increase in motility (N=4, p=0.0463, one tailed paired t test) and tone (N=4) of the proximal colon upon AMPA microinjection in the left SNpc.