TABLE 3.
Intranasal LVS vaccination induced specific protection against i.n. challenge of F. tularensis but not Y. pestis
| Expt no. | Vaccination status | Challenge organism | Survival (no. of survivors/no. tested) | Mean time to death (days) |
|---|---|---|---|---|
| 1a | None | LVS | 0/4 | 6.5 |
| LVS | LVS | 4/4 | ||
| None | NMFTA1 | 0/4 | 5.5 | |
| LVS | NMFTA1 | 4/4 | ||
| 2b | None | NMFTA1 | 0/4 | 5.0 |
| LVS | NMFTA1 | 3/3 | ||
| None | Y. pestis | 0/4 | 4.0 | |
| LVS | Y. pestis | 0/4 | 4.0 | |
| 3c | None | Y. pestis | 0/10 | 3.2 |
| LVS | Y. pestis | 0/10 | 3.6 |
a
Vaccinated BALB/c mice were challenged i.n. with 5 × 104 CFU of LVS or 2 × 102 CFU of NMFTA1. The results show survival ratios on day 16 postinfection.
b
Vaccinated BALB/c mice were challenged i.n. with 2 × 102 CFU of NMFTA1 or 104 CFU of Y. pestis. The results show survival ratios on day 26 postinfection.
c
Vaccinated BALB/c mice were challenged i.n. with 104 CFU of Y. pestis and were monitored until death.