Table 3.
Factors Associated With Kaposi Sarcoma–Associated Herpesvirus (KSHV) Antibody Levels Among KSHV-Seropositive Children
| Factor | Crude | Adjusteda | ||
|---|---|---|---|---|
| Regression Coefficient (95% CI) | P Value | Regression Coefficient (95% CI) | P Value | |
| Malaria | ||||
| RDT−/PfPCR− (uninfected) | Ref | .007* (trend) | Ref | .014* (trend) |
| RDT–/PfPCR+ | 0.12 (−.09 to .33) | 0.13 (−.09 to .35) | ||
| RDT+/PfPCR+ | 0.24 (.06–.43) | 0.25 (.06–.45) | ||
| Age, y | 0.03 (−.01 to .07) | .201 | 0.03 (−.01 to .07) | .190 |
| Sex | ||||
| Male | Ref | .935 | Ref | .867 |
| Female | −0.006 (−.15 to .13) | −0.01 (−.15 to .13) | ||
| Anemia | ||||
| Normal (Hb ≥11.5 g/dL) | Ref | .975 | Ref | .616 |
| Anemic (Hb <11.5 g/dL) | 0.002 (−.15 to .16) | −0.04 (−.20 to .12) | ||
| Body temperature (axillary) | ||||
| ≤37.5°C | Ref | .994 | Ref | .554 |
| >37.5°C | 0.001 (−.16 to .17) | −0.05 (−.22 to .12) | ||
Immunoglobulin G (IgG) to 25 Kaposi sarcoma–associated herpesvirus (KSHV) recombinant proteins was measured using multiplex bead assay. IgG median fluorescent intensity to the 25 KSHV proteins were summed and log10 transformed before linear regression modeling.
Abbreviations: CI, confidence interval; Hb, hemoglobin; PCR–, Plasmodium falciparum polymerase chain reaction negative; PCR+, Plasmodium falciparum polymerase chain reaction positive; RDT–, rapid diagnostic test negative; RDT+, rapid diagnostic test positive.
aAdjusted for age, sex, anemia, body temperature, and malaria parasitemia. RDTs and quantitative real-time PCR were used to determine malaria parasitemia.
* P < .05 considered statistically significant.