Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 10;229(2):462–472. doi: 10.1093/infdis/jiad421

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — Fc effector functions are preferentially transferred across the placenta compared to neutralizing activities. The bars depict the median of matched maternal (grey) and cord (blue) blood levels of (A) neutralization against live SARS-CoV-2 WA1, Delta, and Omicron; (B) ADNKA; (C) ADCD; (D) ADCP; and relative binding to (E) FcRN and (F) FcγRIIIa/CD16a, FcγRIIa/CD32a, and FcγRIIb/CD32b specific to receptor-binding domain. Statistical significance was calculated by Wilcoxon-matched pairs test. Abbreviations: ADCD, antibody-dependent complement deposition; ADCP, antibody-dependent cellular phagocytosis; ADNKA, antibody-dependent natural killer cell activation; FRNT, reduction neutralization test; IFN-γ, interferon-γ; MFI, mean fluorescence intensity; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TNF-α, tumor necrosis factor-α.