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. 2023 Oct 10;229(2):462–472. doi: 10.1093/infdis/jiad421

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — IgG1 is the primary subclass that drives antibody functions. Radar plots summarize the magnitude of RBD-specific IgG and subclass in (A) maternal and (B) matched cord blood. Each line represents the median Z-scored data for each group (infection n = 20, vaccine n = 18, vaccine + infection n = 27). P values are adjusted for maternal age and body mass index using linear regression. ^ Marks significance after adjustment for multiple comparisons by Benjamini-Hochberg. Heatmaps of the regression coefficients (r²) summarize the dependency of RBD-specific antibody functions on subclasses in (C) maternal and (D) cord blood by simple linear regression. *P ≤ .05, **P ≤ .01, ***P ≤ .001, ****P ≤ .0001. Abbreviations: IFN-γ, interferon-γ; IgG, immunoglobulin G; RBD, receptor-binding domain; TNF-α, tumor necrosis factor-α.