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. 2023 Oct 10;229(2):462–472. doi: 10.1093/infdis/jiad421

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Subclass and glycosylation differentially drive neutralizing activities and Fc effector functions in peripheral maternal and cord blood in (A–C) the absence and (D–F) presence of vaccination in pregnancy. A and D, The magnitudes of maternal and cord blood functions are summarized in polar plots. Each slice represents the median Z-scored data for each group. Network matrices summarize the dependency of antibody functions on (B and E) IgG subclasses and (C and F) potency on glycans in maternal (left) and cord (right) blood by simple linear regression. Line colors represent regression coefficients, and width statistical significance (−log P). *P ≤ .05, **P ≤ .01, ***P ≤ .001, ****P ≤ .0001. Abbreviations: ADCD, antibody-dependent complement deposition; ADCP, antibody-dependent cellular phagocytosis; B, bisecting; F, fucosylated; G1, monogalactosylated; G2, digalactosylated; IFN-γ, interferon-γ; IgG, immunoglobulin G; S1, monosialylated; S2, disialylated; TNF-α, tumor necrosis factor-α.