TABLE 1.
Metastatic infections in different organs by S. epidermidis strains in the rat CVC-associated infection model
| Parameter and organ | Result for straina:
|
|||||
|---|---|---|---|---|---|---|
| ATCC 12228 | ATCC 12228-ica | HB | HB-ica | Tü3298 | Tü3298-ica | |
| Liver | ||||||
| No. of rats infected/ total | 3/10 | 7/10 | 2/6 | 8/8 | 6/9 | 7/9 |
| Median (range) CFU/g tissue | 0 (0 × 102-1.3 × 102) | 1.7 × 103 (0 × 105-2.7 × 105) | 1.7 (0 × 102-1 × 102) | 3.8 × 102 (3.3 × 101-6.2 × 103) | 3.3 × 102 (0 × 104-4 × 104) | 1 × 103 (0 × 104-8.3 × 104) |
| P value | 0.019 | 0.0078 | 0.1631 | |||
| Kidney | ||||||
| No. of rats infected/ total | 2/10 | 7/10 | 2/6 | 8/8 | 5/9 | 6/9 |
| Median (range) CFU/g tissue | 0 (0 × 102-2.3 × 102) | 2.7 × 102 (0 × 107-1.3 × 107) | 2.5 × 101 (0 × 102-8.5 × 102) | 2.6 × 103 (3.0 × 102-3.3 × 104) | 6.7 × 102 (0 × 105-3.2 × 105) | 4.3 × 103 (0 × 106-2.7 × 106) |
| P value | 0.015 | 0.0066 | 0.7502 | |||
| Heart | ||||||
| No. of rats infected/ total | 3/10 | 7/10 | 1/6 | 6/8 | 4/9 | 7/9 |
| Median (range) CFU/g tissue | 0 (0 × 102-3.6 × 102) | 3.8 × 102 (0 × 104-7.2 × 104) | 5 (0 × 101-8.3 × 101) | 2.0 × 102 (0 × 103-7.2 × 103) | 0 (0 × 103-2.7 × 103) | 2.3 × 103 (0 × 104-2.9 × 104) |
| P value | 0.023 | 0.0645 | 0.0792 | |||
| Blood | ||||||
| No. of rats infected/ total | 4/10 | 6/10 | 0/6 | 7/8 | 2/9 | 5/9 |
| Median (range) CFU/g tissue | 0 (0 × 102-1.3 × 102) | 1.5 × 102 (0 × 102-4.9 × 102) | 0 (0-0) | 8.6 × 102 (0 × 103-1.75 × 103) | 0 (0 × 102-6.0 × 102) | 10 (0 × 103-8.0 × 103) |
| P value | 0.123 | 0.0037 | 0.2649 | |||
| Infection | ||||||
| Infection rate (%) | 30.0 ± 8.2 | 67.5 ± 5.0 | 20.8 ± 16.0 | 90.6 ± 20.0 | 47.2 ± 19.0 | 69.4 ± 10.6 |
| P value | <0.0001 | <0.0001 | 0.056 | |||
a
For statistical significance (Wilcoxon test), results represent animals challenged with S. epidermidis ATCC 12228, HB, or Tü3298 versus those challenged with S. epidermidis ATCC 12228-ica, HB-ica, or Tü3298-ica.