Fig. 5. Valency of insulin on NanoRods modulates transcriptional responses.

a, Heat map of DEG (P ≤ 0.001; log₂fold change, ±0.58) in adipocyte cultures treated with medium (Control), insulin at 10 or 100 nM, NR-1 at 10 nM of insulin and NR-7 at 10 nM or 100 nM of insulin for 4 h. b, UpSet plot visualizing the total number (blue bars) and shared (black bars) DEG across all the conditions for which DEG were detected. c, GSEA with false-discovery rate adjustment for KEGG pathways enriched (P ≤ 0.05) in cells treated with NR-1 at 10 nM insulin or NR-7 at 10 and 100 nM insulin. The highlighted categories indicate pathways associated with insulin metabolism. INS denotes insulin.

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