Table 4.
Prognostic factors of OS by univariate and multivariate analysis
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Gender (Female vs. Male) | 1.895 (0.761–4.719) | 0.169 | ||
| Age (< 65 vs. ≥ 65) | 1.033 (0.611–1.748) | 0.903 | ||
| Smoking status (Never vs. Former or current) | 1.206 (0.708–2.053) | 0.490 | ||
| Alcohol consumption (Never vs. Former or current) | 1.865 (1.105–3.148) | 0.020 | 1.351 (0.772–2.365) | 0.293 |
| Weight loss (≤ 5% vs. > 5%) | 1.769 (1.070–2.926) | 0.026 | 1.325 (0.757–2.321) | 0.325 |
| KPS (< 90 vs. ≥ 90) | 0.588 (0.362–0.954) | 0.032 | 0.652 (0.381–1.117) | 0.120 |
| Number of primary tumors (Single vs. Multiple) | 1.800 (0.439–7.381) | 0.414 | ||
| Tumor length | 1.097 (1.026–1.172) | 0.006 | 0.991 (0.918–1.070) | 0.820 |
| T stage (T1-3 vs. T4) | 2.218 (1.367–3.601) | 0.001 | 1.650 (0.956–2.847) | 0.072 |
| N stage (N0 vs. N +) | 4.284 (1.047–17.538) | 0.043 | 4.476 (1.075–18.640) | 0.040 |
| M stage (M0 vs. M1) | 1.124 (0.632–1.998) | 0.691 | ||
| Radiotherapy dose (Gy) (≤ 60.2 vs. > 60.2) | 1.224 (0.756–1.982) | 0.411 | ||
| Regimen of concurrent chemotherapy (Single agent vs. Double agents) | 2.717 (1.091–6.764) | 0.032 | 2.960 (1.176–7.451) | 0.021 |
| Whether induced immunotherapy plus chemotherapy was received (No vs. Yes) | 0.412 (0.236–0.719) | 0.002 | 0.443 (0.253–0.777) | 0.005 |
OS: Overall survival; HR Hazard ratio; CI Confidential interval; VS Versus; KPS Karnofsky performance status scale