Table 1.

Summarized list of tumors with myxoid histological appearances and their features (Source: WHO Classifications of Tumors 2020 (3)).

Tumor	Features
Neurofibromas
	S100 positive
	CD34 negative
Superficial angiomyxoma
	Predilection for trunk and head and neck region
	Inflammatory component usually seen
	Positive for CD34
	Negative for S100, SMA, and muscle specific actin
Myxoid dermatofibrosarcoma protuberans (myxoid variant)
	Uncommon
	With storiform pattern
	Positive for CD34
	Negative for EMA
	Diagnostic: 17 and 22 translocations with COL1A1–PDGFB fusion gene
Low-grade fibromyxoid sarcoma
	Deep-seated tumors
	Alternating collagenous and myxoidal areas with rosette formation
	CD34 +/−
Digital mucous cyst/mucinous cyst
	Ganglion-related lesion
	Commonly involving the synovium
	Loose, cystic area
	Low cellularity
Superficial angiomyxoma
	Head and neck region
	Distinctive lobulated pattern
	Inflammatory cells are seen
Low-grade myxofibrosarcoma
	Seen in extremities
	Curvilinear capillary pattern with myeloid matrix
	Perivascular condensation of tumor cells
	Marked nuclear atypia
	Variable for CD34 immunoreactivity
	EMA – negative