Table 2.

List of soft tissue tumors with distal extremity predilection and their features (Source: WHO Classifications of Tumors (3)).

Tumor	Features
Sclerosing perineurioma
	Cell arranged in onion-skin pattern
	CD34 +/−, usually negative
	EMA positive
Acquired digital fibrokeratomas
	Exophytic, paucicellular, with interwoven thick vertical-oriented collagen bundles
	CD34 +/− (not consistent)
	EMA – negative
	S100 – negative
Periungual fibroma
	Multiple in nature
	Associated with tuberous sclerosis
	Abundant fibrous connective tissue
	Vertical-oriented collagen bundles
Acral myxoinflammatory fibroblastic sarcoma
	Virocyte or Reed–Sternberg-like cells with hyaline areas
	Abundant inflammatory cells
	EMA – negative