Figure 1.

The role of non-coding RNA in the immune microenvironment of the maternal-fetal interface. Normal pregnancy is influenced by sociopsychological, genetic, and immune memory environmental factors. Non-coding RNA can act on trophoblast cells and regulate their phenotypes such as proliferation, apoptosis, EMT, autophagy, and angiogenesis. While, M1-type macrophages can transport miRNA to trophoblastic cells through vesicular transport to play a role. Non-coding RNA can also act on macrophages, NK cells, and CD4 T cells to perform physiological functions. When the immune cells of the body lose their correct executive power, RSA can occur.