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. 2024 Feb 16;15:1423. doi: 10.1038/s41467-024-45737-7

Fig. 5. Informativeness of the APL stemness score in predicting prognosis and early death in APL.

Fig. 5

a Profiling of the predicted APL cell type percentage, clinical features, and gene mutations in the 323 APL patients. Columns represent individual APL patients, and the P-values were calculated using the Wilcoxon rank-sum test (statistical tests with two groups) or analysis of variance (ANOVA, with more than two groups) to illustrate the correlation between the APL stem-like cell percentage and clinical features/genetic alternations. Two-sided P-values were calculated. b Examination of the APL stemness score and its relationship to the prognosis of the 323 APL patients. The P-values were calculated using the Wilcoxon rank-sum test to reveal the correlation between the APL stemness score and the prognosis of the 323 APL patients. * PML/RARα isoforms mainly encompass three typical types: long (L), short (S), and variant (V) types, respectively defined by the breakpoint of PML on intron 6, intron 3, and exon 6. OS overall survival, EFS event-free survival, DFS disease-free survival. c, d Kaplan–Meier estimates of overall survival (OS) (c) and event-free survival (EFS) (d) of APL patients (n = 305 patients with prognostic information) in the entire cohort stratified by the APL stemness score. The P-values were calculated using the log-rank test. Two-sided P-values were calculated.