TABLE 1.

Frequency of IgG antibody responses to GST-Arp or B. burgdorferi sonicate according to the manifestation of Lyme disease

Infection stage	Single serum samples from treated patientsa			Serial serum samples from untreated patientsb
	Time after onset of infection	No. positive/total patientsc (%)		Time after onset of infection	No. positive/total patients (%)
		GST-Arp	Sonicated		GST-Arp	Sonicate
Erythema migranse
Acute	1-21 days	13/30 (43)	7/30 (23)	2-12 wks	15/20 (75)	7/19 (37)
Convalescent	16-39 days	16/30 (53)	20/30 (67)
Facial palsy/arthralgia	2-6 wks	19/32 (59)	21/32 (66)	2-12 mo	16/20 (80)	12/19 (63)
Arthritis	6-28 mo	42/62 (68)	59/59 (100)	7-52 mo	15/20 (75)	17/17 (100)

^aThirty patients with culture-confirmed erythema migrans, 32 patients with facial palsy, and 62 patients with arthritis.

^bTwenty patients with untreated Lyme arthritis; serial serum samples were obtained during erythema migrans, during the initial episodes of joint pain (arthralgia), and during the maximal period of arthritis.

^cNumber of patients with positive IgG antibody response/total no. of patients.

^dSonicate results were not obtained in single serum samples from three treated patients and in five samples from three untreated patients because insufficient serum remained.

^eSamples were obtained at the time of initial presentation (acute) and at the conclusion of antibiotic therapy 2 to 4 weeks later (convalescent) in treated patients.