TABLE 1.
Comparison of reactions of 24 subjects to a single oral dose of 109 CFU of Vibrio cholerae 638 and 21 volunteers receiving placebo
| Parameter | No. (%) of volunteers experiencing reaction with the following grade in response to the indicated treatment:
|
P valuec | |||||
|---|---|---|---|---|---|---|---|
| No reaction
|
Milda
|
Moderateb
|
|||||
| 638 (n = 24) | Placebo (n = 21) | 638 (n = 24) | Placebo (n = 21) | 638 (n = 24) | Placebo (n = 21) | ||
| Diarrhea | 20 (84) | 19 (90) | 4 (16) | 2 (10) | 0.670 | ||
| Gurgling | 11 (46) | 11 (53) | 13 (54) | 10 (47) | 0.768 | ||
| Abdominal cramps | 17 (71) | 15 (72) | 7 (29) | 6 (28) | 1.000 | ||
| Headache | 18 (76) | 18 (86) | 5 (20) | 3 (14) | 1 (4) | 0.701 | |
| Vomiting | 24 (100) | 21 (100) | |||||
| Fever | 24 (100) | 21 (100) | |||||
a
Short-duration reaction that did not interfere with the daily activities of the volunteers.
b
Reaction that interfered with but did not impair the daily activities of the volunteers.
c
For vaccine versus placebo recipients.