TABLE 3.
Anti-H. pylori T-cell response in seven infected volunteers
| Marker | Median T-cell numbers (range)a
|
|||||
|---|---|---|---|---|---|---|
| Pit
|
Neck
|
Gland
|
||||
| Pre | Post | Pre | Post | Pre | Post | |
| CD3 | 9.2 (4.8-18.2) | 28.8* (13-39.2) | 11 (6.4-19.8) | 40.4* (21.6-48.2) | 10.8 (5-21.8) | 30.2* (2.6-47) |
| CD4 | 0.6 (0.2-1.6) | 5.6* (1.4-11.8) | 1.4 (0.4-3.6) | 11* (2.4-19.8) | 1.2 (0-2.6) | 9.6* (4.2-22.4) |
| CD8 | 4.6 (2.6-14.4) | 12* (10-33) | 10.8 (4-12.6) | 19.2* (11.8-32.6) | 7.2 (3.6-17.6) | 13.2 (7-14) |
| CD30 | 0.2 (0-2) | 0.4 (0.2-1.4) | 0.8 ± 0.2 | 1 ± 0.3 | 0.5 ± 0.1 | 0.6 ± 0.5 |
n = 7; *, P value of <0.05. Data are divided by the indicated sites and by relation to infection (pre- or postinfection). The T-cell distributions were measured prior to the challenge and at 4 weeks postchallenge. T cells in the three zones (neck, pit, and gland) were counted (n = 7) as described in Materials and Methods. The increase of CD3, CD4, and CD8 cells is statistically significant as assessed by the Wilcoxon rank sum test. CD3 marker reacts with T cells associated with the T-cell antigen receptor; CD4 marker reacts with a subset of T cells that carry the coreceptor protein CD4 that activates macrophages and B-cell responses to antigen; CD8 marker reacts with cytotoxic CD8 cells that recognize antigens; CD30 marker reacts with a tumor necrosis factor receptor family member that enhances B-cell proliferation.