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. 2024 Feb 16;14:3941. doi: 10.1038/s41598-024-54692-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) The heat map of the complex relationship between plasma 20S proteasome ChT-L activity and serum NF-κB1 (p105), NF-κB2 (p100), NF-κB p65 and cerebrospinal fluid MCP-1 concentrations in UIA patients. The utilized color scale and the R values found in individual fields denote the strength and direction (no minus sign for positive correlation, with a minus sign for negative correlation) of the linear relationship between the two variables. Statistically significant dependencies for the examined parameters have been elucidated in the results section. (b) ROC curve for plasma 20S proteasome ChT-L activity and serum NF-κB2 (p100) concentration in differentiating UIA patients from control individuals without vascular lesions in the brain. Legend for Fig. 4a-b: ChT-L, chymotrypsin-like; MCP-1, Monocyte Chemoattractant Protein-1; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; ROC curve, receiver operating characteristic curve; UIA, unruptured intracranial aneurysm.