Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 16;7:191. doi: 10.1038/s42003-024-05878-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — SARS-CoV-2 ACE2-adapted mice were inoculated with either B.1.351 (Beta) or B.1.617.2 (Delta) virus and left for 3 days for virus to proliferate. They were then sacrificed with the lung homogenate used to infect another mouse. This was repeated for ten passages. P10 virus for each lineage was then used to infect three additional mice and the process was repeated for an additional ten passages. P0 and P20 virus for each lineage was subsequently used to infect additional mice to compare weight loss and survival between early and late passage virus, and test non-adapted mouse susceptibility to the virus. Antibody neutralization of virus was also compared.