Skip to main content
. 2024 Feb 16;7:191. doi: 10.1038/s42003-024-05878-3

Table 1.

Annotations of select variants that changed in frequency across the study

Variant Amino Acid Change Annotation Potential Interacting Human Protein Human protein implicated with COVID-19 severity or susceptibility
A929G ORF1ab I222V, nsp2 Protein interacting* GIGYF2, FKBP15*, WASHC4, RAP1GDS1, POR, eIF4E2*, SLC27A2 GIGYF243
C22674T Spike S371F Protein interacting, antibody escape, vaccine target, Omicron-associated variant allele76 GOLGA7, ZDHHC5 GOLGA7, ZDHHC538
A25107G Spike E1182G Protein interacting, vaccine target GOLGA7, ZDHHC5 GOLGA7, ZDHHC538
G28237T ORF8 R115L Protein interacting* COL6A1, PCSK6, LOX*, DNMT1*, NPC2, CISD3, ITGB1, PLAT, STC2, TOR1A, PLOD2*, INHBE, CHPF2, UGGT2, FBXL12, PLEKHF2, SMOC1, POFUT1, FKBP10*, ERLEC1, IL17RA, ADAMTS1, HS6ST2, SDF2, NEU1, GDF15, TM2D3, SIL1, EDEM3, ERP44, PVR, NGLY1, OS9, ADAM9, NPTX1, POGLUT2, POGLUT3, ERO1B, PLD3, FOXRED2, CHPF, PUSL1, HYOU1, MFGE8, FKBP7, GGH, EMC1 COL6A179, LOX46, PLAT80, PLOD242, FBXL1281, FKBP1047, IL17RA82, HS6ST283, NEU184, GDF1585, ADAM986, PLD387

A * indicates a human protein that is druggable.