Table 9:

The correlation between dry eye symptoms and signs, and among signs for participants with and without Sjögrens Syndrome at baseline (n = 1022 eyes)

	rho* (95% Confidence Interval)
	With SS (n= 108 eyes)	Without SS (n= 914 eyes)	Difference (With SS – without SS)
Between OSDI and Four Dry Dye Signs
OSDI vs. Tear break-up time	0.30 (0.08, 0.47)	−0.09 (−0.17, −0.01)	0.39 (0.15, 0.59)
OSDI vs. Schirmer test	0.12 (−0.14, 0.35)	−0.09 (−0.17, 0.01)	0.20 (−0.06, 0.45)
OSDI vs. Corneal staining score	0.01 (−0.26, 0.26)	0.06 (−0.02, 0.15)	−0.06 (−0.33, 0.21)
OSDI vs. Conjunctival staining score	−0.26 (−0.49, −0.01)	0.02 (−0.06, 0.11)	−0.28 (−0.51, −0.03)
Among Four Dry Eye Signs
Tear break-up time vs. Schirmer test	0.37 (0.15, 0.56)	0.15 (0.07, 0.23)	0.21 (−0.01, 0.44)
Tear break-up time vs. Corneal staining score	−0.23 (−0.48, 0.05)	−0.27 (−0.35, −0.19)	0.05 (−0.22, 0.33)
Tear break-up time vs. Conjunctival staining score	−0.44 (−0.63, −0.23)	−0.08 (−0.16, 0.00)	−0.36 (−0.56, −0.13)
Schirmer test vs. Corneal staining score	−0.24 (−0.46, 0.01)	−0.31 (−0.38, −0.23)	0.07 (−0.17, 0.33)
Schirmer test vs. Conjunctival staining score	−0.43 (−0.60, −0.25)	−0.19 (−0.27, −0.12)	−0.24 (−0.42, −0.03)
Corneal staining score vs. Conjunctival staining score	0.56 (0.39, 0.71)	0.28 (0.20, 0.36)	0.29 (0.10, 0.45)

SS= Sjögren Syndrome

Sjögren Syndrome was defined by the 2012 American College of Rheumatology SS classification criteria based on serology and ocular surface staining.

95% confidence intervals (95% CI) were calculated using cluster bootstrap to account for correlation from two eyes of the same patient.