Skip to main content
. 2024 Feb 16;15:1446. doi: 10.1038/s41467-024-45760-8

Fig. 7. Model summarizing our findings.

Fig. 7

Model summarizing our findings. We propose that PAF1c acts downstream of MYC to enhance full-length transcription of long DNA repair genes while limiting the expression of short MHC class I genes. Interference with PAF1c function results in the redistribution of transcription elongation factors, including SPT6. This restores expression of short MHC class I genes and impairs the full-length transcription of long DNA repair genes. This change reshapes the tumor microenvironment, causing immune cell-dependent tumor regression and enabling long-term survival of PDAC-bearing mice.