Table 2.
Summary of SNP/Locus Sex-Combined Associations From Correlated Meta-analysis
| Trait_1_2_3 | SNP | Chr | Loci | Trait_1 p Value* | Trait_2 p Value* | Trait_3 p Value* | CMA p Value* |
|---|---|---|---|---|---|---|---|
| FVC_IL-6_hsCRP | rs67112407 | 7 | NPVF/CYCS | 6.14 × 10−06 | 4.47 × 10−03 | 9.17 × 10−04 | 1.91 × 10−08 |
| FEV1_IL-6_hsCRP | rs17349645 | 7 | CALN1 | 2.34 × 10−05 | 2.06 × 10−04 | 4.89 × 10−04 | 1.20 × 10−09 |
| FVC_IL-6_hsCRP | 2.44 × 10−06 | 2.06 × 10−04 | 4.89 × 10−04 | 2.75 × 10−10 | |||
| FEV1_IL-6_hsCRP | rs34171875 | 14 | TRIM9 | 3.30 × 10−03 | 2.90 × 10−04 | 1.12 × 10−04 | 3.49 × 10−08 |
| FVC_IL-6_hsCRP | 3.85 × 10−03 | 2.90 × 10−04 | 1.12 × 10−04 | 4.86 × 10−08 | |||
| FEV1_IL-6_hsCRP | rs11079574 | 17 | AXIN2/CEP112 | 1.56 × 10−04 | 3.57 × 10−04 | 5.04 × 10−04 | 9.17 × 10−09 |
| FVC_IL-6_hsCRP | rs2896013 | 22 | MICAL3 | 3.77 × 10−06 | 9.38 × 10−05 | 3.17 × 10−03 | 2.12 × 10−08 |
| FEV1_hsCRP | rs8044418 | 16 | CMIP | 6.81 × 10−06 | 1.18 × 10−04 | 9.57 × 10−09 | |
| FEV1_BMI | rs1493126 | 4 | CYP2U1 | 1.54 × 10−05 | 6.15 × 10−05 | 8.70 × 10−09 | |
| FVC_BMI | 6.72 × 10−05 | 6.76 × 10−05 | 4.63 × 10−08 | ||||
| FEV1_BMI | rs144725076 | 14 | MDGA2/RPL10L | 2.41 × 10−05 | 2.51 × 10−04 | 5.47 × 10−08 | |
| FVC_BMI | 1.15 × 10−05 | 2.51 × 10−04 | 3.64 × 10−08 | ||||
| FEV1_BMI | rs7256661 | 19 | LOC105372472 | 1.50 × 10−03 | 1.55 × 10−06 | 3.90 × 10−08 | |
| FVC_BMI | 1.20 × 10−03 | 1.55 × 10−06 | 3.84 × 10−08 | ||||
| FEV1_GRIP | rs9870813 | 3 | XXYLT1 | 1.38 × 10−04 | 4.57 × 10−06 | 7.10 × 10−09 | |
| FVC_GRIP | rs77980484 | 8 | MAL2 | 9.55 × 10−05 | 5.56 × 10−05 | 4.95 × 10−08 | |
| FVC_HbA1c | rs201917736 | 9 | CBWD1/DOCK8 | 4.35 × 10−04 | 1.28 × 10−06 | 8.44 × 10−09 |
Notes: The most significantly associated SNPs per locus within a 1-Mb region; BMI = body mass index; Chr = chromosome; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; GWAS = genome-wide association study; HbA1c = glycosylated hemoglobin; hsCRP = high-sensitivity C-reactive protein; IL-6 = interleukin-6.
*Trait_1 p value = GWAS p value for Trait_1 (FEV1 or FVC); Trait_2 p value = GWAS p value for Trait_2 (IL-6, BMI, Muscle (grip) strength or HbA1c); Trait_3 p value = GWAS p value for Trait_3 (hsCRP); CMA p value = p value for correlated meta-analysis.