Dental caries in experiment 3 after infection with S. sobrinus 6715. The buccal, lingual, total smooth (buccal plus lingual), occlusal, and total molar caries scores from the four immunized groups (11 to 12 rats per group) are shown. Bars indicate the mean caries scores for the respective surface(s) ± 1 standard error of the mean. Asterisks indicate groups that have significantly lower caries scores than those found in the sham-immunized group (shm). The level of significance, determined by one-way ANOVA and the Tukey pairwise multiple-comparison test, is indicated in the left-most panel. The labels on the abscissa indicate sham (shm)-, SYI-CAT (Di)-, SYI (S)-, and CAT (C)-immunized groups.