Table 2.
Demographic and Clinical Data From Patients With Meningitis Associated With Fusarium solani Infection (N = 80)
| Characteristic | Total | Nonsurvivors | Survivors | P Value |
|---|---|---|---|---|
| Meningitis cases, No. (%) | 80 (100) | 41 (51.3) | 39 (48.7) | |
| Age, y, median (IQR) | 30 (24.7–36.2) | 30 (22.5–35) | 30 (25–37.2) | .942a |
| Female, No. (%) | 76 (95) | 40 (97.6) | 36 (92.3) | .353b |
| Surgical procedures, No. (%) | ||||
| Cesarean section | 61 (76.3) | 33 (80.5) | 28 (71.8) | .258b |
| Cholecystectomy | 3 (5.1) | 2 (4.9) | 1 (2.6) | |
| Knee arthroplasty | 3 (3.8) | 2 (4.9) | 1 (2.6) | |
| Hysterectomy | 2 (2.5) | 0 (0) | 2 (5.1) | |
| Ovarian cystectomy | 2 (2.5) | 2 (4.9) | 0 (0) | |
| Natural childbirth | 2 (2.5) | 0 (0) | 2 (5.1) | |
| Orchiectomy | 2 (2.5) | 0 (0) | 2 (5.1) | |
| Bilateral tubal occlusion | 1 (1.3) | 0 (0) | 1 (2.6) | |
| Colpoperineoplasty | 1 (1.3) | 0 (0) | 1 (2.6) | |
| Hysteroscopy | 1 (1.3) | 0 (0) | 1 (2.6) | |
| Osteosynthesis removal | 1 (1.3) | 1 (2.4) | 0 (0) | |
| qPCR results, No. (%) | ||||
| Positive | 31 (38.8) | 19 (46.3) | 12 (30.8) | <.001 b |
| Negative | 26 (32.5) | 2 (4.9) | 24 (61.5) | |
| Without qPCR | 23 (28.7) | 20 (48.8) | 3 (7.7) | |
| Time periods, median (IQR) | ||||
| Incubation daysc | 7 (4–30) | 7 (4–30.5) | 7 (3.7–25.7) | .836a |
| Days of hospitalizationd | 39.5 (18–86.5) | 50.5 (18.7–84.5) | 38 (18–93) | .338a |
| Days since surgery to hospitalization | 78 (52.5–99.7) | 76 (55.5–93.5) | 80 (38–126) | .149a |
| Antifungal onsete, days | 4 (2–9) | 7 (3–11.7) | 3.5 (2–6.2) | .018a |
| Patient management, No. (%) | ||||
| Admission to the ICU | 36 (45) | 34 (82.9) | 2 (5.1) | <.001b |
| Treatment with voriconazole and AmB | 71 (88.8) | 35 (85.4) | 36 (92.3) | .483b |
| Treatment with steroids | 64 (80) | 35 (85.4) | 29 (74.3) | .122b |
Abbreviations: AmB, amphotericin B; ICU, intensive care unit, IQR, interquartile range, qPCR, real-time polymerase chain reaction. Bold values indicate a significant difference.
aPearson χ2.
bKruskal-Wallis.
cIncubation days: Days elapsed between surgical procedure and symptom onset.
dDays of hospitalization: Time from hospital admission until discharge or death.
eVoriconazole and AmB onset time: Time from hospitalization until administration of antifungal treatment.