Table 3.
Point estimates for the 5 phenotypes from MGB at a FPR of 10%.
| Phenotype | Method | AUC | Threshold | TPR | PPV | NPV |
|---|---|---|---|---|---|---|
| CA | ssROC | 81.3 | 64.0 | 51.0 | 89.8 | 51.5 |
| supROC | 80.4 | 73.7 | 35.2 | 87.4 | 40.1 | |
| CHF | ssROC | 83.2 | 84.9 | 42.0 | 44.1 | 89.2 |
| supROC | 79.3 | 86.1 | 36.0 | 43.9 | 86.6 | |
| PD | ssROC | 85.9 | 75.3 | 49.1 | 74.1 | 75.2 |
| supROC | 81.6 | 80.1 | 34.1 | 72.4 | 64.1 | |
| SS | ssROC | 89.4 | 59.8 | 60.6 | 89.9 | 60.7 |
| supROC | 87.5 | 64.6 | 52.3 | 89.7 | 53.2 | |
| T1DM | ssROC | 90.5 | 80.4 | 68.8 | 57.3 | 93.7 |
| supROC | 91.5 | 80.1 | 75.0 | 59.8 | 94.8 |
Abbreviations: CA, cerebral aneurysm; CHF, congestive heart failure; FPR, false positive rate; MGB, Mass General Brigham; NPV, negative predictive value; PD, Parkinson’s disease; PPV, positive predictive value; SS, systemic sclerosis; ssROC, semi-supervised receiver operating characteristic analysis; supROC, supervised receiver operating characteristic analysis; T1DM, type 1 diabetes; TPR, true positive rate.